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Learn more about Wegovy, the revolutionary treatment for weight loss

About Wegovy

A new and ground-breaking injectable weight loss treatment is designed to help you lose weight and keep it off.

Wegovy mimics a natural hormone in the body that targets appetite.

These Wegovy injections have been specifically designed and tested for use as a weight loss treatment and are the most effective weight loss solutions currently available in the UK.

Wegovy weight loss injections come in two higher doses.

How Wegovy Injection Works

The Science of Appetite Control

Wegovy works by mimicking the action of a natural hormone that is released into our bloodstream after meals.  This sends signals to specific regions in the brain responsible for appetite control.

As well as reducing appetite, Wegovy also

  • slows stomach emptying, which makes you feel full for longer.
  • has beneficial effects on blood sugar and insulin levels, which help curb your cravings.

So it’s no surprise that people taking Wegovy find it much easier to decrease their calorie intake by reducing portion size and eating less often.

Slows Stomach Emptying

You Feel Fuller For Longer

Suppresses Appetite

Here's How to Use a Wegovy Injection

There are five different Wegovy pens. Why?

Each Wegovy pen contains a different strength of the active ingredient, semaglutide, starting at 0.25mg and going all the way up to 2.4mg.

This is because it takes time for your body to adjust.  If you started on the highest dose pens, your body would not be able to cope with the challenge and you’d suffer severe side effects such as constant vomiting, bowel disturbance, acid reflux, and bloating.

For this reason, you should always start Wegovy on the smallest starter dose of 0.25mg and gradually step up, one dose at a time, over a period of 5 months.  Using the drug in this way minimises the risk of you getting side effects and having to come off treatment early.

It’s just like training your body for a marathon—you have to be patient!

Some people find that they get good weight loss without having to go all the way to the highest dose pens.

Others find that, despite building up the dose gradually, the stronger Wegovy doses are just too strong and cause a lot of side effects, so they prefer to take things more slowly and stay on a slightly lower-strength pen.

The SemaPen app lets you adjust your subscription so you can choose the pen strength that suits you best.

You’re in control with SemaPen!




Weight Loss with The SemaPen Programme

You can expect to lose an average of 15% of your body weight over 52 weeks of treatment*

*Results are based on the STEP 1 Wegovy Trial. Results vary - weight loss can be more or less than 15% average.

Why stay on Wegovy

According to clinical trials*, Wegovy is most effective when taken for a year, and when it is stopped earlier, most people regain weight quite rapidly.

The SemaPen program lasts for 52 weeks and is designed to maximise and sustain weight loss.


*Rubino, D. et al. (2021) “Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance in adults with overweight or obesity,” JAMA, 325(14), p. 1414.


The best results are achieved if you stay on our programme for at least 12 months*

*Results are based on the STEP 4 Wegovy Trial. Results may Vary.

Common Side Effects

Like most medications, people on Wegovy may experience some side effects, particularly as their dosage increases. The following lists contain some of the most common side effects reported during the clinical trials*


Please note that the suggested remedies are general recommendations for the most common side effects as suggested by the NHS. If you feel like your symptoms are persistent please contact a GP or medical professional for advice.

*Wilding, J.P.H. et al. (2021) “Once-weekly semaglutide in adults with overweight or obesity,” New England Journal of Medicine, 384(11), pp. 989–1002.


Nausea and Bloating

Almost half of people in the Wegovy Clinical trials experienced nausea, one of the most common symptoms reported.  It is was noted particularly when participants increased their dosage. It often goes away as you continue using the drug, but some helpful tips to deal with nausea include:

  • Getting plenty of fresh air
  • Drinking ginger or peppermint tea
  • Eating smaller meals more frequently
  • Sipping cold water throughout the day to avoid dehydration



Diarrhoea was reported in about a third of patients using Wegovy and can be an uncomfortable symptom when starting your treatment. However, many people have reported mild symptoms that subsided over time. Here are a few ways you can manage diarrhoea:

  • Drinking plenty of liquids, including water or juice
  • Avoiding foods that can make your diarrhoea worse including spicy or fatty foods
  • Reduce your caffeine an intake
  • Stick to light, bland foods



A quarter of participants also reported constipation when using Wegovy. Constipation is usually mild and does not persist for long periods of time.  Helpful, simple remedies include:

  • Drinking more fluids: aim for 6–8 glasses per day
  • Adding fibre to your diet. Good sources of fiber include whole grains, nuts and seeds
  • Increase your physical activity where possible
  • Establish a regular bathroom routine and do not delay your urge to use the toilet



Vomiting was also reported in a quarter of users in clinical trials.  Again, this tends to occur as you step up to higher dose pens, or in patients with poor eating habits (eating too much and too quickly despite lacking an appetite). Here are a few helpful tips to manage vomiting:

  • Eat foods that have a high water content, such as cucumbers and soups
  • Reduce your portion sizes and eat smaller meals more frequently; overeating is a common cause of vomiting when taking weight loss injections
  • Slow down when eating
  • Do not eat just for the sake of it when you don’t feel hungry but do make sure you have at least two small meals a day
  • Take regular sips of a cold drink
  • Eat light, bland foods

Headache or Dizziness

Headaches have been reported in 15% of those on the Wegovy treatment. Usually mild, you can manage these symptoms by:

  • Place a hot or cold compress on your forehead
  • Simple painkillers such as paracetamol. It is best to avoid anti-inflammatory drugs like ibuprofen and voltarol
  • Get plenty of rest in a quiet or dark room
  • If you feel dizzy: lie down until the dizziness passes
  • Avoid coffee, smoking and alcohol

Indigestion and Heartburn

Indigestion and heartburn were also associated with taking the Wegovy injections, but only in 1 in 10 patients. To help manage  acid reflux

  • Adjust your sleeping position by raising your pillow or the head of your bed
  • Avoid late meals and eating right before going to bed
  • Identify trigger foods that may increase your heartburn (such as spicy food, wine, onions)
  • Avoid smoking

Other Side Effects

This list is not intended to be a comprehensive list of all possible side effects that have ever been reported with treatment.

However, a useful guide compiled by the manufacturer, Novo Nordisk, can be found here

Side Effects

In clinical trials the Wegovy pens caused side effects preventing normal everyday activities in less than 4% of patients (compared with those taking a placebo dummy injection). However, there are some rare, but potentially more severe Wegovy side effects you should be aware of.

If you experience any of the side effects listed below, stop your treatment immediately and seek medical attention.

Pancreatitis (1 in 500 risk)

Pancreatitis is an inflammation of the pancreas gland (part of the digestive system). It is often mild and self-limiting, but can become serious if left untreated. If you experience sharp, persistent pain in the centre of your stomach and that extends to your back, stop using the pens immediately and seek medical attention.

Gallbladder- Related Disorders (about 1 in 100 risk)

The weight loss injections may cause gallbladder-related disorders including gallstones (cholelithiasis). Common symptoms of gallstones include persistent severe stomach pains under the right rib cage, often with a high fever and sometimes associated with yellowing of the whites of the eyes (known as Jaundice). If you experience any of these side effects please stop taking the medication immediately and seek medical attention.

Injection site reactions (1 in 20 risk) and Allergic Reactions

Whilst reactions such as some swelling, tenderness, redness or itching around the injection site are fairly common, a very serious allergic reaction to the pen is rare.  However, if you have any symptoms of an allergic reaction such as severe rashes and itching, swelling of the tongue, face throat or lips and difficulty breathing or swallowing, stop using the pens immediately and seek urgent medical attention.

For diabetics – Low blood sugar (hypoglycaemia) – Rare

If you have diabetes, or are taking certain diabetes medications such as insulin or another weight loss injection, taking the pens may lead to low blood sugar. We will ask supplementary questions about your diabetes treatments to assess your suitability for the treatment during the SemaPen programme onboarding process.  It is important to make sure to measure your blood sugar levels regularly and speak to your diabetes healthcare professional if you experience any symptoms of hypoglycaemia such as dizziness, anxiety and palpitations, sweating, turning pale or fainting.

Mental health disturbance – Very Rare

Following a small number of  case reports in Iceland and the USA, agencies that monitor the safety of new medicines are assessing a potential link between use of weight loss injections and thoughts of self-harm.  At the time of writing no causal association has been demonstrated, but our advice is to stop your treatment and seek urgent help from your family doctor or mental health practitioner in the unlikely event that you experience suicidal thoughts whilst on the treatment.  In addition, we will send you questionnaires to monitor your mental health during your time on the SemaPen programme.

Changing your Dose if you Experience Side Effects

In some cases, particularly as you start taking higher doses, you may find that you experience increased side effects. This is completely normal, and is the reason why we increase your dose gradually. If you are unable to tolerate the side effects of your new dose, we recommend switching back to your previous dose.

If you are unable to tolerate the side effects of your new dose

We recommend switching back to your previous dose and resuming the SemaPen program at a dose you are comfortable with. This doesn’t mean you will not lose any more weight, but you may find that your rate of weight loss can slow down. You may still see results on the lower dose.

If you want to reduce your dosage

You can reduce your dosage and switch back to your previous month’s pen strength by simply logging into your SemaPen account using the SemaPen app and changing your subscription. Please note that you will need to do this a few days before your next billing, to allow sufficient time for processing.

If you feel satisfied with your current dose

If you are satisfied with your current dose and do not wish to automatically step up to a higher strength pen next month, you can edit your plan details through the SemaPen app. Please note that you will need to do this every month, as our program will automatically upgrade your dose each month.

Have another question?

You can read answers to frequently
asked questions here.