Managing side effects of weight loss drugs

Wegovy and Mounjaro side effects – and how to manage them

Side effects: what to expect

All medications can cause side effects. A side effect is an unwanted result that happens alongside the intended effect of the medication.


Side effects are fairly common with Wegovy and Mounjaro. However, most of these side effects are mild and can be managed quite easily at home.


You're most likely to experience side effects when you start taking Wegovy or Mounjaro or when you first switch to a higher dose. This is also when the side effects are likely to be most pronounced. For many people, the discomfort gets better after a few days.


In this guide, we explain the most common side effects of Wegovy and Mounjaro seen in clinical trials.* We also share tips for managing them.


Please note that the suggested remedies are general recommendations found on NHS websites.


If your symptoms are persistent or severe, contact a GP or another medical professional for advice.

Common side effects of Wegovy and Mounjaro

  • Nausea

    In clinical trials, this was one of the most common side effects of Wegovy for weight loss. It also affected Mounjaro patients, although it was less common with Mounjaro.


    Nausea often goes away as you continue using the drug. In the meantime, you might want to try these remedies:


    • Get plenty of fresh air.
    • Drink ginger or peppermint tea.
    • Eat smaller meals more frequently.
    • Sip cold water throughout the day to avoid dehydration.
  • Diarrhoea

    In clinical trials, about 30% of Wegovy patients reported diarrhoea as a side effect. It also affected Mounjaro patients, though it was less frequent with Mounjaro. Many cases were mild and got better over time.


    You can help reduce the severity of diarrhoea by adjusting your diet.


    • Drink plenty of liquids, including water or juice.
    • Avoid foods that can make your diarrhoea worse, including spicy or fatty foods.
    • Avoid foods and drinks with caffeine (such as coffee).
    • Stick to light, bland foods.
  • Constipation

    Constipation is a fairly common side effect of weight loss drugs. It was experienced by around 23% of Wegovy patients and about 15% of Mounjaro patients in clinical trials.


    Constipation is usually mild and doesn't stick around for long.


    Here are some simple remedies to try if you experience constipation:


    • Drink more fluids: aim for 6 to 8 glasses per day.
    • Add fibre to your diet. Good sources of fibre include whole grains, nuts and seeds.
    • Increase physical activity, where possible.
    • Establish a regular bathroom routine. Don't delay your urge to use the toilet.
  • Vomiting

    Vomiting was also reported as a Wegovy and Mounjaro side effect. This tends to occur when you move to a higher dose. It can also occur when patients eat too much and too quickly, even though they don't have a big appetite.


    Here are a few helpful tips to manage vomiting:


    • Eat foods with a high water content, such as cucumbers and soups.
    • Reduce portion sizes and eat smaller meals more often. Overeating is a common cause of vomiting when taking weight loss injections.
    • Try to eat more slowly.
    • Don't eat for the sake of eating. However, you should make sure you eat at least 2 small meals every day.
    • Sip cold drinks regularly.
    • Eat light, bland foods.
  • Headaches or dizziness

    Headaches are a moderately common side effect of taking Wegovy for weight loss, affecting around 15% of patients in clinical trials. In Mounjaro trials, about 7% of patients reported headaches.


    Headaches are usually mild. You can manage them with these home remedies:


    • Place a hot or cold compress on your forehead.
    • Take basic painkillers like paracetamol. Avoid painkillers with anti-inflammatory properties, such as ibuprofen and Voltarol.
    • Get plenty of rest in a dark, quiet room.
    • If you feel dizzy, lie down until the dizziness passes.
    • Avoid coffee, smoking and alcohol.
  • Indigestion and heartburn

    Indigestion and heartburn are moderately common side effects of weight loss injections.


    To help manage heartburn (acid reflux), try these remedies:


    • Adjust your sleeping position by raising your pillow or the head of your bed.
    • Avoid late meals and eating right before you go to bed.
    • Identify trigger foods that make heartburn worse for you (these might include spicy foods, wine or onions, for example).
    • Avoid smoking.

Mounjaro side effects

These side effects occur from time to time with Mounjaro but are rare or absent with Wegovy.

  • Efficacy of the contraceptive pill

    When oral contraceptives were taken with Mounjaro, the levels of certain hormones in the contraceptives were lowered.


    This means we can't be sure if the oral contraceptive pill will work as well when you're on Mounjaro. If you currently take the contraceptive pill and want to start Mounjaro treatment, it's best to switch to an alternative form of birth control.

  • Hair loss or thinning

    Four per cent of participants in the Mounjaro clinical trial experienced hair loss or thinning. Most of  the cases were mild and the majority of patients got better while still on the treatment. None of the patients who took Mounjaro stopped taking it or left the study because of hair loss.

Serious or long term side effects

Serious and long-term side effects are rare. In clinical trials, side effects that prevented normal activities occurred in fewer than 4% of Wegovy patients and 0.1% of Mounjaro patients (compared with those taking a placebo dummy injection).


However, more severe side effects do happen from time to time. Most of these are just as likely to occur with Wegovy as with Mounjaro.


If you experience any of the side effects below, stop your treatment immediately and seek medical attention

  • Pancreatitis (1 in 500 risk)

    Pancreatitis is an inflammation of the pancreas gland (part of the digestive system). It is often mild and self-limiting but can become serious if left untreated. If you experience sharp, persistent pain in the centre of your stomach that extends to your back, stop using the pens immediately and seek medical attention.

  • Gallbladder-related disorders (about a 1 in 100 risk)

    Gallbladder-related disorders are among the rarer side effects of weight loss drugs. These disorders can include gallstones (cholelithiasis). A common symptom of gallstones is persistent, severe stomach pains under the right rib cage, often with a high fever. Gallstones can also cause yellowing of the whites of the eyes (known as 'jaundice'). If you experience any of these side effects, stop taking the medication immediately and seek medical attention.

  • Injection site reactions (1 in 20 risk on Mounjaro) and allergic reactions

    Reactions such as some swelling, tenderness, redness or itching around the injection site are fairly common. However, a very serious allergic reaction to the pen is rare. Symptoms of an allergic reaction include severe rashes and itching, swelling of the tongue, face, throat or lips and difficulty breathing or swallowing. If you experience any of these symptoms, stop using the pens immediately and seek urgent medical attention.

  • Low blood sugar in patients with diabetes (1 in 100 risk)

    If you have diabetes or are taking certain diabetes medications such as insulin, taking the pens may lead to low blood sugar (hypoglycaemia). We will ask supplementary questions about your diabetes treatments to assess your suitability for the treatment during your SemaPen online consultation. It's important to measure your blood sugar levels regularly and speak to your diabetes healthcare professional if you experience any symptoms of hypoglycaemia. These can include dizziness, anxiety and palpitations, sweating, turning pale and fainting.

  • Gastroparesis (rare)

    Gastroparesis is a very rare condition reported with GLP-1 agonists like Wegovy and Mounjaro. It happens when digestion slows down more than expected.


    All GLP-1 agonists like Wegovy and Mounjaro work (in part) by slowing down stomach emptying to make you feel full more quickly and for longer. In gastroparesis, however, the muscles lining the stomach slow down so much that undigested food can sit in the stomach for hours or even days. Eventually, this undigested food is vomited back out.


    If you're concerned that you might be experiencing gastroparesis or are vomiting frequently, you should contact your clinical support team for professional medical advice.

  • Mental health disturbance (rare)

    Agencies that monitor the safety of new medicines are assessing a potential link between the use of weight loss injections and thoughts of self-harm. This is based on a small number of cases reported in Iceland and the USA.


    At the time of writing, no causal association has been demonstrated. However, in the unlikely event that you experience suicidal thoughts while on the treatment, our advice is to stop treatment immediately. You should also seek urgent help from your family doctor or mental health practitioner. In addition, we will send you questionnaires to monitor your mental health during your time on the SemaPen programme.

Other side effects of Wegovy and Mounjaro

This guide is not intended to be a comprehensive list of all possible side effects that have ever been reported with treatment.


A useful guide compiled by Wegovy's manufacturer, Novo Nordisk, can be found here.


Another guide compiled by Mounjaro's manufacturer, Eli Lilly, can be found here.

Can I change my dose if I experience side effects?

In some cases, particularly as you start taking higher doses, you may find that you experience increased side effects. This is completely normal and is the reason why we increase your dose gradually. If you started taking a higher dose immediately, the side effects would be much worse because your body wouldn't yet have adjusted to the medication.


However, if you're unable to tolerate the side effects of your new dose, we recommend switching back to your previous dose.

 If you're unable to tolerate the side effects of your new dose

We recommend switching back to your previous dose and resuming the SemaPen programme at a dose you're comfortable with. This doesn't mean you will not lose any more weight. However, you may find that your rate of weight loss slows down. You may still see results on the lower dose.

If you want to reduce your dosage

It's easy to reduce your dosage and switch back to your previous month's pen strength. Simply log into your SemaPen account using the SemaPen app and change your subscription. Please note that you will need to do this a few days before your next billing to give us enough time to process the change.

If you feel satisfied with your current dose

Are you satisfied with your current dose and don't wish to automatically step up to a higher-strength pen next month? You can edit your plan details through the SemaPen app. Please note that you will need to do this every month, as our programme will automatically upgrade your dose each month.

Where next?

Our programmes

SemaPen's Mounjaro and Wegovy programmes are designed by real UK obesity experts. Learn how they work and why they're different.

Discover programmes

Pricing

We've worked hard to make our programmes as affordable as possible. See transparent month-by-month pricing here.

Learn more

Guides

Discover more in-depth guides on weight loss injections, how to take them and what to expect during treatment.

Read guides

FAQs

If you have a question about Wegovy or Mounjaro, there's a good chance we've answered it here.

Explore FAQs
Share by:
-->