Managing type 2 diabetes can sometimes feel like you’re juggling a lot, medication, diet, and lifestyle changes all at once. The good news is that with some exciting new weight loss treatments available in the UK, you have more options than ever to help keep your blood sugar levels in check. Two of the most popular choices are Mounjaro and Ozempic. Both of these medications have built a strong reputation for their effectiveness, but they each have their own unique qualities. In this blog, we’ll explore how Mounjaro and Ozempic work, their effectiveness, potential side effects, and costs in the UK, to help you make the best decision for your health.
What Are Mounjaro and Ozempic?
Mounjaro (Tirzepatide)
Mounjaro, or Tirzepatide, is one of the newer medications available in the UK, developed by Eli Lilly and Company. It was recently approved for use and is now available to patients through the NHS and private healthcare providers. Mounjaro is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, meaning it works in two ways to help control blood sugar in adults with type 2 diabetes.
Ozempic (Semaglutide)
Ozempic, from Novo Nordisk, has been available in the UK since 2018. It’s a GLP-1 receptor agonist, which means it mimics the action of a hormone in your body that stimulates insulin production and reduces sugar release from the liver. While Ozempic is well-known for its effectiveness in aiding weight loss, it’s important to note that in the UK, it is specifically approved for blood sugar control in type 2 diabetes, not for weight management. This means that while patients often experience weight loss with Ozempic, it’s not officially endorsed by the NHS for this purposeIfpurpose If you’re interested in learning more about why Ozempic is not approved for weight loss in the UK, click here.
How Do Mounjaro and Ozempic Work?
Mechanism of Action
- Mounjaro: What sets Mounjaro apart is its dual action as both a GIP and GLP-1 receptor agonist. GIP helps trigger insulin release after meals, while GLP-1 slows down stomach emptying, reduces appetite, and lowers glucagon levels. This combination not only controls blood sugar but can also aid in weight loss.
- Ozempic: Ozempic focuses solely on the GLP-1 pathway. It boosts insulin secretion in response to high blood sugar and cuts down the glucose produced by your liver. It also helps you feel fuller for longer, with the added side effect of promoting weight loss.
Effectiveness in Managing Diabetes
Blood Sugar Control
- Mounjaro: Studies have shown that Mounjaro can lead to a more significant reduction in HbA1c levels (a marker of long-term blood sugar control) compared to some existing diabetes treatments, including Ozempic. Many patients see a greater drop in HbA1c when using Mounjaro.
- Ozempic: While Ozempic (Semaglutide) might not lower HbA1c quite as much as Mounjaro, it’s still a powerful option, particularly for those who respond well to GLP-1 receptor agonists. Many people have successfully hit their blood sugar targets with Ozempic.
Weight Loss
- Mounjaro: Alongside its blood sugar-lowering effects, Mounjaro has shown impressive results in promoting weight loss. Its dual action could be especially beneficial for those who are managing both type 2 diabetes and obesity.
- Ozempic: Ozempic is recognised in the UK for its weight loss benefits, but it is primarily approved for managing type 2 diabetes, not for weight management. It is not suitable for non-diabetic individuals and should not be used by those without diabetes. For those specifically seeking a weight loss treatment Wegovy is the right option, as it contains the same active ingredient (semaglutide), is approved in the UK for this purpose. If you’re considering buy Wegovy in UK, you can check your eligibility online here.
Side Effects of Mounjaro and Ozempic
Common Side Effects
- Mounjaro: Common side effects with Mounjaro include nausea, diarrhoea, reduced appetite, and vomiting. These tend to be mild and often improve as your body gets used to the medication.
- Ozempic: Similar to Mounjaro, Ozempic can cause nausea, diarrhoea, and vomiting. Some people also report constipation, stomach pain, and a slight risk of pancreatitis.
Serious Side Effects
- Mounjaro: While it’s not common, studies do point out that Mounjaro can have some serious side effects. These include severe allergic reactions, pancreatitis, and hypoglycemia, particularly if you’re taking it with other diabetes medications.
- Serious side effects of Ozempic may include pancreatitis, kidney problems, and the potential for thyroid tumours. It’s important to keep an eye out for any unusual symptoms and speak to your GP if you’re concerned.
Dosage and Administration
- Mounjaro: Mounjaro is typically taken once a week via injection. It comes in various strengths ranging from Mounjaro 2.5 mg to Mounjaro 15 mg, with the starting dose typically being 2.5 mg, gradually increasing based on the patient’s tolerance and blood sugar control needs. The highest dose, 15 mg, is reserved for those requiring the most significant reduction in blood glucose levels.
- Ozempic: Similar to Mounjaro, Ozempic is also administered as a once-weekly injection, with doses of 0.25 mg, 10.5 mg, and 2 1 mg. Doctors usually start patients on a lower dose and gradually increase it to help minimize side effects while effectively managing blood sugar levels.
Mounjaro and Ozempic Cost Comparison in the UK
- Mounjaro: As Mounjaro is relatively new, it might be more expensive and not yet available through all NHS trusts. However, many authorised private suppliers offer it at discounted prices, along with additional clinical support for eligible patients. At SemaPen, we provide a competitive price for Mounjaro in the UK, along with a smart digital scale and 1:1 clinical support. Curious about the cost of Mounjaro through the SemaPen Programmeme? Click here to learn more.
- Ozempic: Ozempic is generally more widely covered by the NHS, but it can still be pricey if you choose to go private. Novo Nordisk also offers savings Programmemes for those who qualify. However, it’s important to note that the NHS advises against purchasing cheap Ozempic pens available on platforms like Facebook and warns against off-label use. At SemaPen, we strictly adhere to MHRA guidelines and do not offer Ozempic in our Programme. However, we do provide the option to buy Wegovy for eligible patients.
Which Is Right for You?
Choosing between Wegovy, Mounjaro, and Ozempic really comes down to your individual health needs, how your body reacts to the medication, and what your GP recommends. If weight loss is your main goal and you don’t have diabetes, Wegovy could be the right choice for you. On the other hand, if you’re managing type 2 diabetes and also want to shed some extra weight, Mounjaro might be a better fit.
In the UK, it’s important to remember that Ozempic is specifically approved for treating type 2 diabetes, not for weight loss. It’s generally best to avoid using Ozempic for weight loss, especially through private providers outside of the NHS.
Disclaimer:
This post is intended for informational purposes only and should not be considered a substitute for professional medical advice, diagnosis, or treatment. If you have diabetes or any other health condition and are considering medication changes, please consult with your GP. It is essential to discuss any new treatment options to determine what is best for your individual health needs.