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Does Mounjaro Need to be Refrigerated? Your Go-To Guide


If you have recently purchased Mounjaro, you may be wondering what the best way to store it. Proper medication storage isn’t just a good practice; it’s essential for ensuring the effectiveness and safety of your treatment. 

Mounjaro’s active ingredient, Tirzepatide, targets both appetite and metabolism by acting on specific hormone receptors, offering a dual approach to weight management. Available as a pre-filled injection pen in various doses, the correct storage of Mounjaro, from refrigeration before use to handling once opened, is key to its success in your weight loss journey. 

This guide offers vital details on storing Mounjaro (tirzepatide) to ensure its continued effectiveness and safety for weight loss. 


Storing Unused Mounjaro Pens 


Storing your unused Mounjaro pen is straightforward but crucial. These pens need to be stored in the fridge, ideally at temperatures between 2°C and 8°C (36°F to 46°F). Maintaining this cool range is essential to keeping your medication effective. Also, don’t forget to check the expiration date on both the pen and the box to ensure they’re still valid. Never let your Mounjaro pens freeze, as freezing can significantly impact their effectiveness. If a pen does end up frozen, it must be discarded properly.  



Planning a Trip with Mounjaro Pen? 


After you’ve taken the first dose from your Mounjaro pen, the storage requirements become a bit more relaxed. You can keep it at a comfortable room temperature, provided it doesn’t exceed 30°C (86°F), and you have a 30-day window to use it. Just be mindful to keep it away from excessively hot places or direct sunlight. If any medication remains after and you haven’t finished it, it’s time to safely dispose of the pen. 

Buy Tirzeptide (Mounjaro)

Essential Tips for Optimal Mounjaro Pen Storage 


Now that you’re familiar with how to store your Mounjaro pens before and after use, here are a few more tips to ensure optimal storage: 

  • Needle Safety First: Always use a fresh needle for each injection to minimise the risk of infections or contamination. It’s crucial not to reuse or share needles with others, and remember, storing the pen with a needle attached is not advisable for maintaining Properly dispose of used needles in your dedicated sharps container.
  • Inspect the Pen Before You Inject: Take a moment to examine the pen and the medication itself before use. The medication should be completely clear, without any discoloration. If there are any signs of wear on the pen or if the medication looks cloudy, has changed colors, or has particles floating around, it’s safer not to use it.
  • Travelling with Mounjaro: If you’re planning to travel with your Mounjaro pens, consulting with your weight loss programme provider or the Semapen team well in advance is a good idea. They can offer advice on maintaining your medication’s condition, such as using insulated containers for temperature control.
  • Check Manufacturer Website: For the most accurate and up-to-date instructions on storing your medication, always refer to the Mounjaro patient information leaflet or consult the official website of Eli Lilly and Company, the manufacturer. These sources provide the latest guidance on proper storage practices for your medication.


Semapen’s Pro Tips on Mounjaro Storage


  • Choosing the Right Spot: Store your unused Mounjaro pens in a part of the fridge that’s easily accessible but safe from extreme cold or warmth. This strategic placement helps avoid the risks of the pens accidentally freezing or being exposed to temperatures that could affect their effectiveness.
  • Reminder Magic: Develop a habit of setting reminders to dispose of any pens you’ve been using for over 30 days. This simple strategy can significantly ensure that you’re always using your medication safely and effectively.
  • Got Questions?: If you’re ever uncertain about how to store your Mounjaro pens or the cost of a Mounjaro pen, don’t hesitate to contact the Semapen team for expert advice. If you’re not part of the Semapen Weight Loss Programme, consulting your healthcare provider for personalised support and guidance is a wise decision.


Ensuring your Mounjaro (tirzepatide) pens are stored correctly is key to their performance and your safety. By adhering to the advice we’ve shared for handling both new and used pens, you’re setting yourself up for. Always rely on the manufacturer’s guidelines and your healthcare team’s expertise if you find yourself in doubt or needing further direction. 

Download the manufacturing guide on how to use the Mounjaro pen.